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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DYRK2
All Species:
25.15
Human Site:
T557
Identified Species:
39.52
UniProt:
Q92630
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q92630
NP_003574.1
601
66652
T557
V
K
R
I
T
E
S
T
G
A
I
T
S
I
S
Chimpanzee
Pan troglodytes
XP_509205
601
66595
T557
V
K
R
I
T
E
S
T
G
A
I
T
S
I
S
Rhesus Macaque
Macaca mulatta
XP_001117134
601
66643
T557
V
K
R
I
T
E
S
T
G
A
I
T
S
I
S
Dog
Lupus familis
XP_538273
601
66656
T557
V
K
R
I
T
E
S
T
G
A
I
T
S
I
S
Cat
Felis silvestris
Mouse
Mus musculus
Q5U4C9
599
66538
T555
V
K
R
V
T
E
S
T
G
A
I
T
S
I
S
Rat
Rattus norvegicus
Q4V8A3
586
65492
P542
S
G
K
R
V
V
N
P
T
N
A
F
Q
G
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511087
546
60615
T502
V
A
R
R
A
P
E
T
T
G
A
I
T
S
I
Chicken
Gallus gallus
Q5ZIU3
526
59419
G483
K
R
I
T
E
S
T
G
A
I
T
S
I
S
K
Frog
Xenopus laevis
NP_001088793
567
63329
Q523
S
G
K
R
I
T
S
Q
T
S
S
F
P
G
I
Zebra Danio
Brachydanio rerio
NP_001038298
587
65453
T543
V
K
R
I
T
E
G
T
G
A
I
T
S
I
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P83102
828
92722
S611
G
G
V
S
G
L
C
S
S
R
N
E
S
P
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_001023208
796
87422
K752
E
L
F
V
D
F
L
K
R
C
L
D
W
D
P
Sea Urchin
Strong. purpuratus
XP_799140
561
63192
G517
L
P
K
P
P
A
D
G
H
A
N
T
T
S
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P51566
467
54180
L424
I
D
L
L
Q
G
L
L
R
Y
D
P
T
E
R
Baker's Yeast
Sacchar. cerevisiae
P14680
807
91227
S744
Y
G
S
A
N
D
S
S
N
N
A
G
H
N
Y
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.5
99.6
98.3
N.A.
97
59.7
N.A.
78.6
81.3
64.5
83.6
N.A.
43.3
N.A.
45.7
63.7
Protein Similarity:
100
98.8
99.8
99
N.A.
98.5
71.8
N.A.
83
84.5
75
89.8
N.A.
54.9
N.A.
55.6
73.5
P-Site Identity:
100
100
100
100
N.A.
93.3
0
N.A.
20
0
6.6
93.3
N.A.
6.6
N.A.
0
13.3
P-Site Similarity:
100
100
100
100
N.A.
100
13.3
N.A.
26.6
20
20
93.3
N.A.
13.3
N.A.
13.3
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.3
27.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
36.6
41.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
7
7
7
0
0
7
47
20
0
0
0
7
% A
% Cys:
0
0
0
0
0
0
7
0
0
7
0
0
0
0
0
% C
% Asp:
0
7
0
0
7
7
7
0
0
0
7
7
0
7
0
% D
% Glu:
7
0
0
0
7
40
7
0
0
0
0
7
0
7
0
% E
% Phe:
0
0
7
0
0
7
0
0
0
0
0
14
0
0
0
% F
% Gly:
7
27
0
0
7
7
7
14
40
7
0
7
0
14
0
% G
% His:
0
0
0
0
0
0
0
0
7
0
0
0
7
0
0
% H
% Ile:
7
0
7
34
7
0
0
0
0
7
40
7
7
40
14
% I
% Lys:
7
40
20
0
0
0
0
7
0
0
0
0
0
0
7
% K
% Leu:
7
7
7
7
0
7
14
7
0
0
7
0
0
0
7
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
7
0
7
0
7
14
14
0
0
7
0
% N
% Pro:
0
7
0
7
7
7
0
7
0
0
0
7
7
7
7
% P
% Gln:
0
0
0
0
7
0
0
7
0
0
0
0
7
0
0
% Q
% Arg:
0
7
47
20
0
0
0
0
14
7
0
0
0
0
7
% R
% Ser:
14
0
7
7
0
7
47
14
7
7
7
7
47
20
40
% S
% Thr:
0
0
0
7
40
7
7
47
20
0
7
47
20
0
0
% T
% Val:
47
0
7
14
7
7
0
0
0
0
0
0
0
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% W
% Tyr:
7
0
0
0
0
0
0
0
0
7
0
0
0
0
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _